Imagine you are doing a multiple choice exam, and you know that you made a wrong choice in the first question. How would it affect how you answer the next question and your subsequent performance? Recent research finds out that our brain ‘pauses’ after we made a mistake, leading to the decrease in accuracy of […]
Here is a selection of short, fun and interesting videos recommended by the King’s Hub. There is something for every scientist, with maths, physics, biology and chemistry related content. Although they are great to watch purely as entertainment, the King’s Hub also loves these videos because they show the wonderful (and slightly weird) knowledge that science […]
How Does The Human Body React to Being in Space? Introduction Following on from Issue 19 which looked at the International Space Station (ISS) and Tim Peake’s life and work on it1, this article aims to look into the fundamental ways that an astronaut’s biological systems change in space, down to the level of their […]
The Zoological Society of London (ZSL) is keen to encourage students to see biology as an inspiring and exciting field of study. Linda DaVolls tells us about ZSL’s annual Prince Philip Award and Marsh Prize! If you are reading this then it’s probably safe to assume that you have more than a passing interest in […]
Why do people age? This has always been an age-old question of humanity. We all know that we do not live forever and that life on our planet will end one day. Life comes with death, but it is a natural process. It is an imposed order that mankind lives up to.
Until the 1970’s, people did not know what telomeres were and what their function is in our organs. Hence, aging had been a mystery. Between 1975 and 1977 Elisabeth Blackburn, a postdoctoral fellow at Yale University, together with Joseph Gail discovered telomeres. Later in 2009 Elisabeth Blackburn was awarded the Nobel Prize in Physiology or Medicine for her discovery.
Current diagnostic approaches to neurodegenerative diseases are often flawed as they are often invasive and cannot effectively diagnose early-onset dementia. Antibody-based therapeutics for neurodegenerative diseases are very promising but often lack specificity to certain biomarkers and require invasive methods of administration such as a lumbar puncture. In this study I report a novel quantum-dot (QD) conjugated bispecific-antibody (BsAb) diagnosis system designed for Alzheimer’s disease. This structure is easy to synthesize and displays specificity to oligomeric amyloid-beta (Aβ), which is often present before Alzheimer’s symptoms starts to manifest. The bispecific antibody also binds with a weak affinity to transferrin receptors – thus potentially allowing it to cross the blood-brain barrier (BBB) via receptor-mediated transcytosis and reducing the necessity for extremely- invasive means of administration such as a lumbar puncture. The CdTe/ZnS QDs conjugated to the BsAb have multimodal, non-invasive MRI and fNIR imaging capabilities and also displayed allow cytotoxicity to neuronal cells. The synthesized nanoparticles composed of CdTe/ZnS with a Gd-DOTA doped silica shell also displayed therapeutic properties by immobilizing the toxic oligomeric Aβ and increasing neuronal viability. These novel BsAb-QD structures display promising diagnostic and therapeutic properties and represent an important evolution in neurodegenerative drug design.
I synthesized a novel nanoparticle-bound antibody for the earlier diagnosis and treatment of Alzheimer’s disease which proves to be less invasive and more accurate in comparison to existing tests of its kind.
The gut microbiota (also referred to as gut flora) is the population of bacteria that colonizes the human gut. There have been 50 bacterial species that have been described, but the human gut microbiota is dominated by 2 particular species: Bacteroidetes and Firmicutes. Other species such as Proteobacteria, Verrucomicrobia, Actinobacteria, Fusobacteria, and Cyanobacteria are much […]
Bleeding, or Exercise Induced Pulmonary Haemorrhage (EIPH), is one of the most common problems experienced by racehorses and can only really, by clinical evaluation, be identified through loss of blood from the nose, which to most would appear relatively serious.  (Figure a.) (Figure a.) However, there is evidence to suggest that nearly every racehorse […]
We all know the environments physical effects upon an organism are apparent, but have you ever considered what effect it has upon us on a genetic level. This is a difficult concept that has intrigued many scientists and encouraged them research into it further. It is only recently that our basis of knowledge and the technological advancements […]
Here, we are faced with the fixed, biological complexity of the brain and the intricate concept, which is open to vast influential change, of one’s mind. The question proposes the task of whether the understanding of the brain or that of the mind holds more significance. However, what this discussion essentially requires is the […]