King's Hub: Videos You Should Watch

Posted on Leave a commentPosted in Biology, blog, blogs, Chemistry, Environment, Health, Health Sciences, Mathematics, Physics

Here is a selection of short, fun and interesting videos recommended by the King’s Hub. There is something for every scientist, with maths, physics, biology and chemistry related content. Although they are great to watch purely as entertainment, the King’s Hub also loves these videos because they show the wonderful (and slightly weird) knowledge that science […]

We do not live forever

Posted on Posted in Biology

 Why do people age? This has always been an age-old question of humanity. We all know that we do not live forever and that life on our planet will end one day. Life comes with death, but it is a natural process. It is an imposed order that mankind lives up to.

Until the 1970’s, people did not know what telomeres were and what their function is in our organs. Hence, aging had been a mystery. Between 1975 and 1977 Elisabeth Blackburn, a postdoctoral fellow at Yale University, together with Joseph Gail discovered telomeres. Later in 2009 Elisabeth Blackburn was awarded the Nobel Prize in Physiology or Medicine for her discovery.

Development of a New Antibody-Based Diagnostic Approach for the Earlier Diagnosis and Treatment of Alzheimer’s Disease

Posted on Leave a commentPosted in Biology

Current diagnostic approaches to neurodegenerative diseases are often flawed as they are often invasive and cannot effectively diagnose early-onset dementia. Antibody-based therapeutics for neurodegenerative diseases are very promising but often lack specificity to certain biomarkers and require invasive methods of administration such as a lumbar puncture. In this study I report a novel quantum-dot (QD) conjugated bispecific-antibody (BsAb) diagnosis system designed for Alzheimer’s disease. This structure is easy to synthesize and displays specificity to oligomeric amyloid-beta (Aβ), which is often present before Alzheimer’s symptoms starts to manifest. The bispecific antibody also binds with a weak affinity to transferrin receptors – thus potentially allowing it to cross the blood-brain barrier (BBB) via receptor-mediated transcytosis and reducing the necessity for extremely- invasive means of administration such as a lumbar puncture. The CdTe/ZnS QDs conjugated to the BsAb have multimodal, non-invasive MRI and fNIR imaging capabilities and also displayed allow cytotoxicity to neuronal cells. The synthesized nanoparticles composed of CdTe/ZnS with a Gd-DOTA doped silica shell also displayed therapeutic properties by immobilizing the toxic oligomeric Aβ and increasing neuronal viability. These novel BsAb-QD structures display promising diagnostic and therapeutic properties and represent an important evolution in neurodegenerative drug design.

I synthesized a novel nanoparticle-bound antibody for the earlier diagnosis and treatment of Alzheimer’s disease which proves to be less invasive and more accurate in comparison to existing tests of its kind.

The Effect of Antibiotics on the Gut Microbiota

Posted on Leave a commentPosted in Biology, Featured, Health

The gut microbiota (also referred to as gut flora) is the population of bacteria that colonizes the human gut. There have been 50 bacterial species that have been described, but the human gut microbiota is dominated by 2 particular species: Bacteroidetes and Firmicutes. Other species such as Proteobacteria, Verrucomicrobia, Actinobacteria, Fusobacteria, and Cyanobacteria are much […]

Exercise Induced Pulmonary Haemorrhage in Horses

Posted on Leave a commentPosted in Biology

Bleeding, or Exercise Induced Pulmonary Haemorrhage (EIPH), is one of the most common problems experienced by racehorses and can only really, by clinical evaluation, be identified through loss of blood from the nose, which to most would appear relatively serious. [1] (Figure a.) (Figure a.) However, there is evidence to suggest that nearly every racehorse […]