Gene Therapy for Sensorineural Hearing Loss

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Abstract Sensorineural hearing loss is an impairment that affects more than 360 million people worldwide. Recent studies suggest that 1.1 billion people could develop the disease during their lives.¹ Despite its widespread effects, the medical disability currently has no cure. However, gene therapy is an emerging treatment, designed to tackle the root causes of this […]

A Possible Consequence of Intravenously Infusing Antibodies into the Immune System

Posted on 2 CommentsPosted in Biology, Health, Health Sciences, Medicine, Neuroscience

Acute Tubular Necrosis (ATN) From Intravenous Immune Globulin (IVIG) Treatment for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Abstract: Infusions of IVIG are used to treat immune deficiency states, autoimmune disorders, and infections. IVIG Explanation and its relation to the Immune System: The immune system is a network of tissues and organs that work to defend the […]

How can cancer be targeted without killing healthy cells?

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Targeted Therapy: a tremendous solution Abstract: Targeted therapy is a relatively new method of curing cancer that uses drugs to attack targets on which cancer cells’ growth closely depend. [1] By attacking the proteins or enzymes responsible for their abnormal growth, its effects are amplified. Targeted therapy is successful in curing many cancer patients, it […]

A New Look At Pancreatic Cancer

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Inhibitory Effects of Flufenamic Acid on YAP-TEAD Activity through the Hippo Signaling Pathway in Murine Pancreatic Adenocarcinoma Cells (LTPA) Robin Hu Abstract Pancreatic adenocarcinoma, accounting for about 85% of pancreatic cancer cases, has poor prognosis and survival rates; novel therapies are needed [1,2]. A core pathway in cancer development is the Hippo Signaling Pathway: a […]

History of Arabic Alchemy

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While reading Jim Al-Khalili’s book “Pathfinders: The Golden Age of Arabic Science” it became apparent that scientific collaboration is essential to achieve meaningful progress. Great advances were made in the medical profession during the Golden Age. The Golden Age occurred during the Abbasid rule which was between the 8th century and the 12th century CE. […]

How Positron Emission Tomography works

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This post aims to explain what positron emission tomography (PET) is and how it works. PET is a unique type of medical imaging that reveals information about the physiology of organs and tissues, unlike CT or MRI machines which only yield images of anatomy. By doing this, PET scans can often detect irregularities such as […]

Sudden Cardiac Arrest in Young Athletes

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Sudden Cardiac arrest in the young may seem uncommon (2 deaths per 100,000 people) but is a fatal end for many passionate athletes. These tragedies appear to be unexpected as they are asymptomatic leading fans and spectators to wonder how a perfectly ‘healthy’ football player could suddenly collapse. Athletes under the age of 35 predominantly […]

PCSK9 Inhibitors – a solution for familial hypercholesterolaemia and ischaemic heart disease?

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PCSK9 stands for Proprotein Convertase Subtilisin Kexin type 9 and it was first discovered in 2003[1] by Dr. Seidah et al. and it is a 692-amino acid glycoprotein.[2] PCSK9 is secreted by the liver into the circulation[3] and it controls the “number of low-density lipoprotein receptors (LDLR) on the cell surface”[4] and therefore ultimately the […]

Hypoplastic Left Heart Syndrome

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What is Hypoplastic left heart syndrome? Hypoplastic left heart syndrome (HLHS) is a rare congenital heart defect which occurs in approximately 1 in 5000 babies. The term ‘hypoplastic’ refers to the underdevelopment of a tissue or an organ. Therefore HLHS involves the underdevelopment, or sometimes absence, of left-sided heart structures. For example, the left ventricle, […]